Why a healthy plate still leaves you tired
Your vegetables carry less than your grandmother's did.
Same carrot. Less inside it.
That's the half you can see. The other half is in you: a gene almost nobody checks. It decides how much of the B9 in your food your cells can use, and your energy runs on B9.
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Check your multivitamin for these two words
If it says “folic acid”, here's what to look for instead.
Folic acid is the cheap synthetic form of B9. Your body has to convert it before your cells can use it, and in 40–60% of adults the gene that does that runs slow.
Look for L-methylfolate instead. It's B9 already converted, so there's nothing to wait on.
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3 things nobody tells you about MTHFR
It might not be your age.
Reading the same paragraph three times. Walking into a room and forgetting why. Energy gone before the day is.
Before you put it down to age, here's what nobody tells you about a gene called MTHFR.
It's common enough to feel normal.
40–60% of adults carry an MTHFR variant. So what it does gets blamed on age, work or stress.
It slows the step your energy runs on.
MTHFR turns B9 from food and vitamins into the form your brain and cells use. A variant slows that step by 30–70%, so you can eat perfectly and still be short of fuel.
Most vitamins use the form that waits on it.
Most multivitamins and fortified foods use folic acid, which has to go through that same slow step. B9 that's already converted skips it.
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Less in the food. Less of it converted.
Leading health experts call it “hidden hunger”. You're full, and your cells are still short.
On your plate
Fruit and vegetables have lost up to 38% of their vitamins and minerals over the last 70 years.
Journal of the American College of Nutrition
In your body and your vitamins
40–60% of adults carry an MTHFR variant that slows B9 conversion by 30–70%. And most vitamins use folic acid, the form that has to wait on it.
Frontiers in Psychiatry
B9 feeds methylation, and methylation controls more than 200 functions in your body: making energy, your mood, building and repairing your DNA.
And when that process is compromised, your cells can't turn food into fuel. The result? Your body runs in “emergency mode”.
And if that gap isn't filled, it can lead to serious (and sometimes irreversible) consequences.
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STUDIES SHOW
71% higher risk of high blood pressure in people who inherit the variant from both parents
Meng, Frontiers in Genetics 2021, meta-analysis of 63 studies
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STUDIES SHOW
36% higher risk of depression in people who inherit the variant from both parents
Gilbody, American Journal of Epidemiology 2007
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STUDIES SHOW
Enzyme activity falls to about a third in people who inherit the variant from both parents
Frosst, Nature Genetics 1995
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STUDIES SHOW
23–32% higher risk of stroke across all MTHFR carriers
Study published in BMC Geriatrics, 2019
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STUDIES SHOW
64% of patients with stroke and type 2 diabetes carry MTHFR variants, against 36% without
Study published in Diabetic Medicine, 2006
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STUDIES SHOW
48% higher risk of ischaemic stroke in adults with two MTHFR variants
Study published in Stroke, 2006
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STUDIES SHOW
Raised homocysteine in 60–90% of people with chronic fatigue and fibromyalgia who carry MTHFR variants
Study published in Clinical Chemistry and Laboratory Medicine, 2020
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STUDIES SHOW
2–8% loss of grey matter volume in MTHFR carriers
Study published in Diabetic Medicine, 2006
Here's the truth:
Standard vitamins are “dead fuel”
More vegetables can't close this gap. More coffee only pushes a system that's short of raw material. And most vitamins make it worse.
Their folic acid is the synthetic form your body can't process. To your body it isn't food. It's a proven toxin.
For healthy methylation you need the natural, already-methylated form. The one your body recognises straight away and uses for energy on the spot. Luckily, that form now exists.
What you can do about it
To beat hidden hunger, you need a steady supply of the key bioactive nutrients that drive methylation.
Every. Single. Day.
And the only way to do that is to take them in their already-methylated forms, which your body can use straight away.
Methylfolate, combined with selected B vitamins and betaine (TMG), restores and feeds the main biochemical process that runs your energy, mood and longevity.
That's the Cellova kit: B9 already active, the B12, B6 and B2 that work beside it, and TMG for the body's second route. 21,000+ people take it every day.
Here's what the research shows for healthy methylation:
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STUDIES SHOW
30% lower homocysteine after 3 months
Study published in Molecular Vision, 2020
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STUDIES SHOW
126% more endurance under physical load
Study published in International Journal of Medical Sciences, 2023
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STUDIES SHOW
Better blood-vessel lining function after B vitamins
Study published in Circulation, 2000
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STUDIES SHOW
Thicker cortex and better brain physiology
Study published in Molecular Psychiatry, 2017: 12 weeks of L-methylfolate
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STUDIES SHOW
Significant improvement in overall mental health, with less stress
Study published in Psychopharmacology, 2010
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STUDIES SHOW
36% more reps in strength training
Study published in PMC, 2022
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STUDIES SHOW
32% response to L-methylfolate in depression that SSRIs had not helped
Study published in American Journal of Psychiatry, 2012
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STUDIES SHOW
7.5% lower LDL cholesterol with methylfolate + P5P + methylcobalamin
Study published in Nutrients, 2024
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STUDIES SHOW
Significantly better body composition (fat ↓, muscle ↑)
Study published in PMC, 2013
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STUDIES SHOW
Slower cognitive decline with B vitamins taken for more than 12 months
Meta-analysis published in Nutrition Reviews, 2022
60-day money-back guarantee
The benefits build over time
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Week 1
Fill in what's missing
As the gaps close, you'll notice steadier daily energy and a more balanced mood.
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Week 2
Clarity comes back
Your focus sharpens, your motivation gets stronger and your head feels steadier.
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Week 3
Mental lift and resilience
You have more emotional and physical stamina, and a clearer, more engaged mind.
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Month 1
Whole-body recalibration
Your methylation cycles settle. Your nervous system, your heart and your sleep and recovery start working in sync.
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Month 2 and beyond
Long-term activation
Your mood, your thinking and your heart keep getting better as methylation, detox and brain support settle into a rhythm.
From €2.09 a day | 60-day guarantee
What the leading experts say
Why the active form is in the protocols of the world's best:
Up to 60% of the population has an MTHFR gene mutation. That means you CANNOT process folic acid effectively. You need methylfolate.
Folic acid is basically a square wheel to your body. It has to be processed by many different enzymes so your body can turn it into a round wheel — L-methylfolate.
Methylfolate and methyl B12 work together to control methylation reactions that regenerate your DNA and brain cells.
People with MTHFR mutations have a significantly higher risk of depression, anxiety and cognitive decline.
Methylfolate is the main circulating form of folate, used to produce serotonin, dopamine and norepinephrine.
Optimizing methylation with the right forms of B vitamins is one of the most powerful interventions in functional medicine.
Homocysteine is one of the best markers of methylation status. If it's above 10 µmol/L, you have a problem worth addressing.
Methylation is one of the key markers I track in Blueprint.
For my patients with autoimmune conditions, optimizing methylation with methylated B vitamins is a critical part of the protocol.
These days I don't take many supplements. But B12 and methylfolate are non-negotiable for me.
Para melhores resultados, toma-o durante pelo menos 3 meses.
O que inclui o kit?
L-Methylfolate⁺ 5 mgA forma biologicamente ativa do folato
Advanced B-Complex8 vitaminas B de alta qualidade
TMG⁺Trimetilglicina, um dador de metilo
Visão geral e benefícios
50% das pessoas têm uma variante do gene MTHFR que bloqueia o último passo da ativação do folato. Quando isso acontece, a metilação abranda e tudo — humor, desintoxicação, produção de energia — sofre. O L-Methylfolate⁺ dá-te a forma totalmente ativa da vitamina B9, pronta a usar assim que chega à tua corrente sanguínea. Em combinação com as vitaminas do complexo B certas e a betaína (TMG), os efeitos são máximos. ✔ Apoia a metilação adequada para a desintoxicação, reparação do ADN e resiliência celular ✔ Promove a síntese saudável de neurotransmissores (serotonina, dopamina, noradrenalina) ✔ Supera os problemas de absorção do folato ligados às variantes MTHFR ✔ Apoiado por médicos, laboratórios de genética e profissionais clínicos ✔ Uma fórmula potente, sem agentes de enchimento — testada por laboratório independente. 5 mg de L-metilfolato puro — uma fórmula avançada para o controlo da homocisteína, humor mais estável, apoio ao sistema nervoso e maiores necessidades metabólicas.
Ingredientes
L-Methylfolate 5 mg: 5 mg de L-metilfolato (de 7,1 mg de sal de cálcio de L-5-metilfolato) · 255 mg de glicina — apoia a estabilidade e a absorção · Celulose vegetal (cápsula), celulose microcristalina — Advanced B-Complex: Vitamina C (como palmitato de ascorbilo) – 15 mg (17%) · Tiamina (B1) – 25 mg · Riboflavina 5'-fosfato (B2) – 25 mg · Niacinamida (B3) – 150 mg NE · Vitamina B6 (piridoxina HCl + P5P) – 55 mg · Vitamina B12 (metilcobalamina) – 1 000 µg · Biotina – 400 µg · Ácido pantoténico (B5) – 150 mg · Colina (bitartarato) – 50 mg · Inositol – 50 mg · PABA – 50 mg · Celulose vegetal (cápsula), celulose microcristalina — TMG Betaína (2 cápsulas): 1 000 mg de trimetilglicina (betaína anidra) · 5 mg de zinco (picolinato de zinco) · Celulose vegetal (cápsula), celulose microcristalina — O que não contém: Sem ácido fólico sintético. Sem estearato de magnésio. Sem glúten, soja, laticínios, frutos de casca rija, ovos, excipientes, conservantes ou agentes de enchimento artificiais. Fabricado segundo as normas GMP. Testado por laboratório independente quanto à pureza, potência e metais pesados.
Qualidade testada
Cada ingrediente e dose nos suplementos da Cellova Health são testados por laboratório independente. Este processo garante que o que vês no rótulo é 100% o que recebes. Ou seja, sabes exatamente o que o teu organismo está a receber.
Como tomar
Uma cápsula de metilfolato, uma cápsula de vitaminas B e 2 cápsulas de betaína por dia. Recomendamos de manhã, para não te esqueceres. Mas qualquer hora serve, com ou sem alimentos.
Conservação
Conserva em local fresco e seco, ao abrigo da luz solar direta — não é preciso frigorífico.
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Formulated by doctors
Clinically proven
Quality tested
Vegan
No fillers or GMOsTry it for 60 days, risk-free
You'll sleep, function and feel better within 60 days. Or we'll simply give you your money back, even if you send back empty bottles.
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