I decided to take them for two months before booking my bloods so I'd have something to compare against. The numbers came back in order and I've moved to the subscription so I don't have to think about it.

Active folate that reaches your cells. From €1,99 a day.
The Cellova kit: L-Methylfolate⁺, Advanced B-Complex and TMG⁺ — the three forms your body uses immediately, no processing needed. Subscribe and save 10%, with free shipping.
Why methylated folate is in the protocols of the world's top practitioners.
- 60-day guarantee
- Tested quality
The kit
One protocol instead of three separate supplements.
L-Methylfolate⁺, Advanced B-Complex and TMG⁺ cover the whole methylation cycle: the active folate, the cofactors that drive it, and the betaine for the second pathway. One protocol, instead of three brands in the cupboard.
- 60-day guarantee
- No fillers, non-GMO

Why the active form
With an MTHFR variant, folic acid never reaches the cells.
Over 50% of people carry an MTHFR gene variant that slows the conversion of folic acid into a usable form. L-Methylfolate is already in the active 5-MTHF form, so the body uses it immediately — that step never happens.
- Tested quality
- Formulated by physicians

From published studies
What the studies on active folate show
- 30%
- Lower homocysteinewith 3 months of use
- 126%
- Greater enduranceunder physical load
- 36%
- More repsin strength training
- 32%
- Response in depressionin SSRI-resistant patients
Studies on L-methylfolate and methylated B vitamins: Molecular Vision 2020 · International Journal of Medical Sciences 2023 · PMC-indexed 2022 · American Journal of Psychiatry 2012.
The benefits for body and mind

For the body
For the mind
Start the whole protocol today.
For best results, take it for at least 3 months.
60-day guarantee · 4.8★ from 274 reviews
Overview & benefits
50% of people carry an MTHFR gene variant that blocks the last step of folate activation. When that happens, methylation slows and everything — mood, detox, energy production — suffers. L-Methylfolate⁺ gives you the fully active form of vitamin B9, ready to use the moment it reaches your bloodstream. Combined with the right B vitamins and betaine (TMG), the effects are strongest. ✔ Supports proper methylation for detox, DNA repair and cellular resilience ✔ Promotes healthy neurotransmitter synthesis (serotonin, dopamine, norepinephrine) ✔ Overcomes the folate-absorption problems tied to MTHFR variants ✔ Backed by physicians, genetic labs and clinical practitioners ✔ A potent, filler-free formula — third-party tested. 5 mg pure L-methylfolate — an advanced formula for homocysteine control, steadier mood, nervous-system support and higher metabolic demand.
Ingredients
L-Methylfolate 5 mg: 5 mg L-methylfolate (from 7.1 mg calcium salt of L-5-methylfolate) · 255 mg glycine — supports stability and absorption · Plant cellulose (capsule), microcrystalline cellulose — Advanced B-Complex: Vitamin C (as ascorbyl palmitate) – 15 mg (17%) · Thiamine (B1) – 25 mg · Riboflavin 5'-phosphate (B2) – 25 mg · Niacinamide (B3) – 150 mg NE · Vitamin B6 (pyridoxine HCl + P5P) – 55 mg · Vitamin B12 (methylcobalamin) – 1,000 µg · Biotin – 400 µg · Pantothenic acid (B5) – 150 mg · Choline (bitartrate) – 50 mg · Inositol – 50 mg · PABA – 50 mg · Plant cellulose (capsule), microcrystalline cellulose — TMG Betaine (2 capsules): 1000 mg trimethylglycine (anhydrous betaine) · 5 mg zinc (zinc picolinate) · Plant cellulose (capsule), microcrystalline cellulose — What it doesn't contain: No synthetic folic acid. No magnesium stearate. No gluten, soy, dairy, nuts, eggs, excipients, preservatives or artificial fillers. Made in a GMP-compliant facility. Third-party tested for purity, potency and heavy metals.
Tested quality
Every ingredient and dose in Cellova Health supplements is third-party tested. That process guarantees what you see on the label is 100% what you get. In other words, you know exactly what your body is taking.
How to take
One Methylfolate capsule, one B-vitamin capsule, and 2 Betaine capsules a day. We recommend mornings, so you don't forget. But any time works, with or without food.
Storage
Store in a cool, dry place away from direct sunlight — no fridge needed.
The benefits of healthy methylation build over time

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Week 1
Fill in what's missing
As the gaps close, you'll notice steadier daily energy and a more balanced mood.
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Week 2
Clarity comes back
Improved neurotransmitter function brings better focus, stronger motivation and steadier brain performance.
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Week 3
Mental lift and resilience
Better emotional and physical stamina, less overwhelm, and a clearer, more engaged mind.
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Month 1
Whole-body recalibration
Methylation cycles stabilize. The nervous system, cardiovascular function and your sleep-and-recovery rhythm start to sync up.
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Month 2 and beyond
Long-term activation
Mood, cognition and cardiovascular function keep improving. Long-term folate intake settles methylation, detox and brain support into a rhythm.
From €1,99 a day | 60-day guarantee
Customer reviews
What customers say
Rating breakdown Filter
What customers rate
Mood balance4.8
Physical health4.76
Value4.22
What customers say
- 97% of reviewers rated it four stars or higher.
- Most talked about: energy, everyday, mood.
- Mood balance scores highest, at 4.8 out of 5.
- 214 of 274 reviews come from a verified purchase.
Summary generated from 274 customer reviews.
Showing 6 of 274 reviews
Two months of nothing, and if I hadn't paid for three up front I'd have quit. Month three brought sleep, month four energy, and by month five my head cleared. Patience was the whole trick.
Bought the set because I was fed up ordering three different bottles from three different places. Turns out they also work better together than they did separately. Works out cheaper a month as well.
Before we started trying, my gynaecologist told me to drop the ordinary folic acid and move to the active form. I took the bundle so all three came from one place. I'm on month five and I'm not planning to change.
I'm in the gym five times a week and what I was after was quicker recovery. For six weeks now I'm not dragging my legs the next day and the last sets go easier.
I had trouble sleeping and a fair bit of anxiety, and honestly I didn't believe vitamins would do anything. Turns out I was wrong. I'm in my third month and something new keeps showing up each month.
What the leading experts say
Why healthy methylation is in the protocols of the world's best:
Up to 60% of the population has an MTHFR gene mutation. That means you CANNOT process folic acid effectively. You need methylfolate.
Folic acid is basically a square wheel to your body. It has to be processed by many different enzymes so your body can turn it into a round wheel — L-methylfolate.
Methylfolate and methyl B12 work together to control methylation reactions that regenerate your DNA and brain cells.
People with MTHFR mutations have a significantly higher risk of depression, anxiety and cognitive decline — all of which can improve with the right methylated supplementation.
Methylfolate is the main circulating form of folate, used to produce serotonin, dopamine and norepinephrine.
Optimizing methylation with the right forms of B vitamins is one of the most powerful interventions in functional medicine.
Homocysteine is one of the best markers of methylation status. If it's above 10 µmol/L, you have a problem worth addressing.
Methylation is one of the key markers I track in Blueprint. It's measurable, it's optimizable, and it's critical for longevity.
For my patients with autoimmune conditions and multiple sclerosis, optimizing methylation with methylated B vitamins is a critical part of the protocol.
These days I don't take many supplements. But B12 and methylfolate are non-negotiable for me, for their key role in homocysteine control and longevity.
Why Cellova
A cleaner formula, a better form, a real result.
Разликата е в молекулата.
Try it for 60 days, risk-free
You'll sleep, function and feel better within 60 days. Or we simply give you your money back — even if you return empty bottles.
Try the kit≈ €1,99 a day | 60-day guarantee
Frequently asked questions
What is methylation?
The process your cells use to produce energy, repair DNA and balance hormones. It happens 300 billion times a day — and it depends on folate.
When will I feel it?
Most people feel more energy and clearer focus within 2–4 weeks. Consistency delivers the result.
What makes active folate better?
5-MTHF is the form the cell uses directly. Regular folic acid has to be converted first — and over half of people do that slowly.
Is it safe to take daily?
Yes. 5-MTHF is the form of folate your body uses naturally. Vegan capsule, no fillers, in the doses from the clinical studies.
How does the 60-day guarantee work?
You have 60 days to try the formula. Return the bottle within that window and you get your money back — even if it's empty.
How much is shipping?
We ship across the EU. Free over €100 — the rate and delivery time show at checkout.