Healthy Methylation Kit

4.8 · 274 reviews

The three formulas that cover the whole methyl cycle — in one kit.

  • L-Methylfolate⁺ — the active folate your cells absorb right away.
  • Advanced B-Complex⁺ — the eight active B-vitamins for energy and metabolism.
  • TMG⁺ — a methyl donor for normal homocysteine levels.

For best results, take it for at least 3 months

5-MTHF dose 1mg
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Choose your plan

  • Formulated by physicians
  • Clinically backed doses
  • Tested quality
  • Vegan, no fillers, non-GMO

What's in the kit

  • L-Methylfolate⁺ L-Methylfolate⁺ 1mg Active 5-MTHF · 30 capsules × 3
  • Advanced B-Complex⁺ Advanced B-Complex⁺ 8 active B forms · 90 capsules × 1
  • TMG⁺ TMG⁺ Trimethylglycine · 60 capsules (2 a day) × 3

3-month supply of each formula

Benefits

The three formulas cover the whole methyl cycle: active folate for methylation, the eight B cofactors for energy, TMG for homocysteine.

Together they support a steadier mood, sharper focus and calmer energy through the day.

Over half of people process folic acid slowly — active 5-MTHF skips that blockage.

Ingredients

L-Methylfolate⁺ — active 5-MTHF (calcium salt), ready to absorb.

Advanced B-Complex⁺ — eight B-vitamins in bioactive forms, including methyl-B12.

TMG⁺ — trimethylglycine (anhydrous betaine), a second methyl route for homocysteine.

Vegan capsules, no fillers. Full labels are under "Full ingredients".

How to take

L-Methylfolate: 1 capsule a day

B-Complex: 1 capsule a day

Trimethylglycine: 2 capsules a day

The best time to take them is in the morning, after food. Keep in a dry place, out of reach of children and pets.

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Formulated by physicians
Clinically proven
Tested quality

Three synergistic formulas for optimal methylation

Methylation is a cycle. Each formula takes on a different step of it.

Methionine SAMe SAH Homocysteine CH₃ 1 2 3 Methionine SAMe SAH Homocysteine CH₃ 1 2 3
1 and 2 feed the same step — turning homocysteine back into methionine. 3 drives the whole loop.
  1. 1
    L-Methylfolate⁺Hands over the methyl groups. An active form the cell uses immediately.
    What it does
    • Bypasses the slow MTHFR step
    • Ready-to-absorb 5-MTHF form
    • Supports energy, focus and mood
  2. 2
    TMG⁺Guards the reserve. A second donor for the same step when folate runs short.
    What it does
    • 1000 mg trimethylglycine per serving
    • Keeps homocysteine in the normal range
    • A reserve for the heavier days
  3. 3
    Advanced B-Complex⁺Drives the cycle. The eight B-vitamins the other two can't work without.
    What it does
    • Eight B-vitamins in one capsule
    • Active forms: methyl-B12, P-5-P, R-5-P
    • Supports energy metabolism
See the science

Why the whole kit

The three formulas cover the cycle end to end. An ordinary supplement covers one line on the label.

Cellova Ordinary supplements
The whole cycleDonor, reserve and cofactors — in one protocol.
Active formsMethyl-B12, P-5-P, 5-MTHF — ready for the cell.
Clinical dosesThe amounts from the studies.
No fillersVegan capsule, nothing extra.
Independently testedEvery batch.
60-day guaranteeReturn it even empty.

The benefits build over time

  1. Week 1

    Fill in what's missing

    As the gaps close, you'll notice steadier daily energy and a more balanced mood.

  2. Week 2

    Clarity comes back

    Improved neurotransmitter function brings better focus, stronger motivation and steadier brain performance.

  3. Week 3

    Mental lift and resilience

    Better emotional and physical stamina, less overwhelm, and a clearer, more engaged mind.

  4. Month 1

    Whole-body recalibration

    Methylation cycles stabilize. The nervous system, cardiovascular function and your sleep-and-recovery rhythm start to sync up.

  5. Month 2 and beyond

    Long-term activation

    Mood, cognition and cardiovascular function keep improving. Long-term folate intake settles methylation, detox and brain support into a rhythm.

Methylation is a daily process — give it at least 12 weeks.

What the leading experts say

Why the active form is in the protocols of the world's best.

  • Gary Brecka

    Gary Brecka

    Human Biologist · Ultimate Human Podcast

    Up to 60% of the population has an MTHFR gene mutation. That means you CANNOT process folic acid effectively. You need methylfolate.
  • Dr. Ben Lynch

    Dr. Ben Lynch

    Naturopath · author of "Dirty Genes"

    Folic acid is basically a square wheel to your body. It has to be processed by many different enzymes so your body can turn it into a round wheel — L-methylfolate.
  • Dave Asprey

    Dave Asprey

    Founder of Bulletproof · "father of biohacking"

    Methylfolate and methyl B12 work together to control methylation reactions that regenerate your DNA and brain cells.
  • Dr. Rhonda Patrick

    Dr. Rhonda Patrick

    Biochemist · FoundMyFitness

    People with MTHFR mutations have a significantly higher risk of depression, anxiety and cognitive decline.
  • Andrew Huberman

    Andrew Huberman

    Neuroscientist · Stanford · Huberman Lab Podcast

    Methylfolate is the main circulating form of folate, used to produce serotonin, dopamine and norepinephrine.
  • Dr. Mark Hyman

    Dr. Mark Hyman

    Functional-medicine pioneer · Cleveland Clinic

    Optimizing methylation with the right forms of B vitamins is one of the most powerful interventions in functional medicine.
  • Dr. Chris Masterjohn

    Dr. Chris Masterjohn

    PhD · Nutritional Sciences

    Homocysteine is one of the best markers of methylation status. If it's above 10 µmol/L, you have a problem worth addressing.
  • Bryan Johnson

    Bryan Johnson

    Founder of Blueprint · the "Don't Die" movement

    Methylation is one of the key markers I track in Blueprint.
  • Dr. Terry Wahls

    Dr. Terry Wahls

    Clinical professor · University of Iowa

    For my patients with autoimmune conditions, optimizing methylation with methylated B vitamins is a critical part of the protocol.
  • Tim Ferriss

    Tim Ferriss

    The Tim Ferriss Show

    These days I don't take many supplements. But B12 and methylfolate are non-negotiable for me.

Customer reviews

What customers say

4.8 out of 5 4.8 out of 5 from 274 reviews

Rating breakdown Filter

What customers rate

Mood balance4.8

Physical health4.76

Value4.22

What customers say

  • 97% of reviewers rated it four stars or higher.
  • Most talked about: energy, everyday, mood.
  • Mood balance scores highest, at 4.8 out of 5.
  • 214 of 274 reviews come from a verified purchase.

Summary generated from 274 customer reviews.

Filter by topic

Showing 6 of 274 reviews

5 out of 53 months ago

I decided to take them for two months before booking my bloods so I'd have something to compare against. The numbers came back in order and I've moved to the subscription so I don't have to think about it.

Mood balance5 out of 5Body health5 out of 5Value for money5 out of 5
Reneta R.Verified purchase
5 out of 53 months ago

Two months of nothing, and if I hadn't paid for three up front I'd have quit. Month three brought sleep, month four energy, and by month five my head cleared. Patience was the whole trick.

Mood balance5 out of 5Body health5 out of 5Value for money4 out of 5
Valentin Zh.Verified purchase
5 out of 53 months ago

Bought the set because I was fed up ordering three different bottles from three different places. Turns out they also work better together than they did separately. Works out cheaper a month as well.

Mood balance5 out of 5Body health5 out of 5Value for money5 out of 5
Antonia Zh.Verified purchase
5 out of 53 months ago

Before we started trying, my gynaecologist told me to drop the ordinary folic acid and move to the active form. I took the bundle so all three came from one place. I'm on month five and I'm not planning to change.

Mood balance5 out of 5Body health5 out of 5Value for money4 out of 5
Desislava T.
5 out of 54 months ago

I'm in the gym five times a week and what I was after was quicker recovery. For six weeks now I'm not dragging my legs the next day and the last sets go easier.

Mood balance5 out of 5Body health5 out of 5Value for money4 out of 5
Todor B.Verified purchase
5 out of 54 months ago

I had trouble sleeping and a fair bit of anxiety, and honestly I didn't believe vitamins would do anything. Turns out I was wrong. I'm in my third month and something new keeps showing up each month.

Mood balance5 out of 5Body health5 out of 5Value for money5 out of 5
Lachezar B.Verified purchase

Frequently asked questions

What is L-methylfolate, and how is it different from folic acid?

L-methylfolate (5-MTHF) is the active form of folate — folate in the exact form your body can use immediately. Folic acid is a synthetic form that has to be converted through multiple steps in your body, and many people struggle with that conversion (in fact, over 50% carry a gene variation that slows it down).

L-methylfolate skips the bottleneck. The result? Better absorption and effectiveness, especially for the brain and mood benefits. It's like giving your body folate fuel that's already ready to burn — which makes the results more reliable. Every Cellova Health product that provides folate uses L-methylfolate of the highest concentration and purity, so you get the full benefit of this vital vitamin.

What is "methylation", and why does it matter for your health?

Methylation is a fundamental biochemical process in your body: a "methyl" group (one carbon plus three hydrogens) gets attached to other molecules. It sounds complex, but it happens in every cell, every second — and it's decisive for many functions: from regulating neurotransmitters (which shape mood and brain function) to detoxifying chemicals, maintaining immune function, and even switching genes on and off.

Think of methylation as your body's maintenance and regulation system. When it runs well, you get better energy, better mood and better overall health. Nutrients like folate, B12, B6 and choline are its key drivers — which is exactly why Cellova Health focuses on them. By supporting methylation, we address a root cause that can drive broad improvements in health.

In short: healthy methylation = a healthier life.

Who can benefit from L-methylfolate supplements?

They're built for anyone who wants to optimize mood, brain function and long-term wellbeing. You don't need a diagnosed condition or a genetic mutation to benefit — these nutrients support the everyday functions all of us run on. That said, people with certain health concerns tend to notice the most.

If you carry an MTHFR gene variant, or process folate poorly, our L-methylfolate and B-Complex can make a particularly big difference. And even if you're broadly healthy but want to keep your edge and protect your health long-term, extra methylation and antioxidant support is exactly what the kit is for.

How do I pick the right dose (1 mg, 2.5 mg, 5 mg, 10 mg)?

Nutritional needs vary a lot from person to person, and the right L-methylfolate dose depends on your situation. The range exists so the dose can match it: 1 mg is great for general maintenance, or if you're just starting out — it covers the basics and gives mood and metabolic health a light assist.

2.5 mg is a moderate step up — useful if you have a mild folate shortfall or want extra mood and cognitive support beyond your diet. 5 mg is a high dose, often chosen by people with known folate-absorption issues, higher stress loads, or on a practitioner's advice for more pronounced mood support.

10 mg is our maximum strength for advanced needs — typically used when a health professional has recommended a very high folate intake, for example as part of a therapeutic plan for mood or metabolic support. If you're not sure, start with 1 mg or 2.5 mg, watch how you feel, and adjust as needed.

People with confirmed MTHFR mutations or higher folate needs can consider 5 mg or 10 mg, though it's worth consulting a doctor at the highest doses. Remember, more isn't always better — what matters is finding the dose where you feel the benefits. We're glad to help: write to us and tell us your situation.

How long until I see results?

Everyone's body is different, but many of our customers say they feel improvements within a few weeks. Mood and mental clarity can start improving after 2–3 weeks of daily L-methylfolate (brain fog often lifts even faster). Energy levels and stress resilience typically improve over the first month, as your methylation processes optimize.

Subtler changes — homocysteine balance, cardiovascular markers, long-term wellbeing measures — can take 2–3 months of consistent use to show measurable differences. The key is consistency: taking it daily lets the effect build and do its job properly.

It's a bit like filling a tank: you may not feel each drop, but you'll definitely know when it's full. We recommend tracking how you feel for at least 8 weeks. And remember, we're here to support you — if anything feels off, write to us: a dose adjustment or adding a cofactor like B-Complex usually makes the difference.

Where do you source your ingredients?

We only choose ingredients that clear four requirements — ultra-pure, high-quality, easily absorbed, and of proven origin. We buy raw materials exclusively from established industry leaders in the US, Germany, France, Japan and Italy, and test every one of them in an independent, accredited laboratory. Suppliers have to meet strict testing and quality criteria to qualify to work with Cellova Health.

Are there side effects? Is it safe long-term?

Every ingredient we use is generally recognized as safe and absorbed naturally by your body. L-methylfolate doesn't usually cause side effects. In very rare cases, very high doses can bring mild headache or irritability — usually resolved by taking B12 and B6 alongside (one more reason our range includes a B-Complex).

None of our products are habit-forming, and none require cycling. All are designed for daily use and long-term health support. As with any supplement, stick to the recommended use — taking more than the recommended dose usually adds no benefit and can raise the chance of side effects.

For a healthy adult, our supplements are very safe to take long-term to maintain the benefits. Plenty of our customers — team members included — have taken them for years.

When is the best time to take L-methylfolate?

Morning is the best time for L-methylfolate and a methyl B-complex, since they support energy production and brain function — that way you get the benefit across the whole day. Many people also take choline in the morning for extra brain support.

More questions about the kit

Try it for 60 days, risk-free

You'll sleep, function and feel better within 60 days. Or we simply give you your money back — even if you return empty bottles.

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